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所在位置:所有产品 > 抗体抗原 > 一抗 > COL4A3抗体
COL4A3抗体图片
产品货号:
Z15466
中文名称:
COL4A3抗体
英文名称:
Anti-COL4A3 Antibody
产品规格:
50μl|100μl|150μl
发货周期:
1~3天
产品价格:
询价
抗体名称Anti-COL4A3 Antibody
指标别名COL4A3;Tumstatin;Goodpasture antigen;Collagen alpha-3(IV) chain
克隆性Polyclonal
检验物种human
应用范围IHC,ELISA
基因名称COL4A3
抗体来源Rabbit
抗体类型IgG
免疫原E.coli-derived human COL4A3 recombinant protein (Position:P1426-H1670).
成分500μg/mL antibody with PBS,0.02% NaN3,1mg BSA and 50% glycerol.
纯化方式Immunogen affinity purified.
浓度500μg/mL
产品形态溶液
保存条件12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing.
背景资料Collagen alpha-3(IV) chain is a protein that in humans is encoded by the COL4A3 gene.Type IV collagen,the major structural component of basement membranes,is a multimeric protein composed of 3 alpha subunits.These subunits are encoded by 6 different genes,alpha 1 through alpha 6,each of which can form a triple helix structure with 2 other subunits to form type IV collagen.This gene encodes alpha 3.In the Goodpasture syndrome,autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli.The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein.A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis.This gene is also linked to an autosomal recessive form of Alport syndrome.The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region.Like the other members of the type IV collagen gene family,this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.
Uniprot IDQ01955
推荐配套试剂Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot.
基因名全称collagen type IV alpha 3 chain
蛋白名全称Collagen alpha-3(IV) chain
推荐稀释比
Immunohistochemistry in paraffin section IHC 1:50~400
ELISA 1:100~1000
(Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user.

相关搜索:COL4A3抗体COL4A3多抗Anti-COL4A3 Antibody
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