产品货号：
Z15466
中文名称：
COL4A3抗体
英文名称：
Anti-COL4A3 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-COL4A3 Antibody |
| 指标别名 | COL4A3;Tumstatin;Goodpasture antigen;Collagen alpha-3(IV) chain |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | IHC,ELISA |
| 基因名称 | COL4A3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human COL4A3 recombinant protein (Position:P1426-H1670). |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Collagen alpha-3(IV) chain is a protein that in humans is encoded by the COL4A3 gene.Type IV collagen,the major structural component of basement membranes,is a multimeric protein composed of 3 alpha subunits.These subunits are encoded by 6 different genes,alpha 1 through alpha 6,each of which can form a triple helix structure with 2 other subunits to form type IV collagen.This gene encodes alpha 3.In the Goodpasture syndrome,autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli.The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein.A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis.This gene is also linked to an autosomal recessive form of Alport syndrome.The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region.Like the other members of the type IV collagen gene family,this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. |
| Uniprot ID | Q01955 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | collagen type IV alpha 3 chain |
| 蛋白名全称 | Collagen alpha-3(IV) chain |
| 推荐稀释比 | Immunohistochemistry in paraffin section IHC 1:50～400 ELISA 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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